Ewan McGregor is on a mission to the ends of the earth to immunise some of the hardest-to-reach children in the world. Against the odds, Ewan and his team deliver vaccines to the world's most remote children as health workers do every day. But their fragile nature means the vaccines must be kept constantly cold as they are passed along the supply chain, from freezer to freezer - wherever that may be. The routes these vaccines travel are known as cold chains, and a vast network of them exists across the globe. In this series Ewan is following three of the world's toughest cold chains, supported by Unicef, who immunise over half of the world's children. In the second episode, Ewan journeys up the mighty Congo River, where he passes through frontier towns in the wilds of Central Africa, encounters a unique subculture for whom style is a religion, and ventures deep into the jungle in search of Pygmy tribes. These two programmes give Ewan an opportunity to go to three very different countries, three situations, and find out just how much it takes to save children's lives. Ewan said of his experience: 'The cold chain routes these vaccines follow can be hugely challenging and adventurous, and I was keen to explore some of them to discover how they reach the world's most remote children.